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DuPage Medical Group is one of the largest and most successful independent multi-specialty physician groups in Illinois, with more than 700 physicians in over 100 suburban Chicago locations.
Learn more about Dimethylglycine uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Dimethylglycine. 3401 Independence Drive Suite 231 Birmingham, Alabama 35209 Phone: 800.227.2627 Store Hours: 8:00 AM - 6:00 PM Mon-Fri (CST). DMG has been used by Russian athletes for well over 3 decades and with the fortification of panax ginseng root and gingko biloba, the synergistic effect of this product vastly improves the benefits to the entire body, hence GAMA DMG/TMG can truly be regarded as the INTERNATIONAL DAILY WELL-BEING ENERGY SOURCE SUPPLEMENT!
Life ExtensionSAMe Costs Too Much!
SAMe has been shown in clinical studies to be the fastest acting safest and possibly, most effective antidepressant ever found. One study found that 66% of patients treated with SAMe showed significant clinical improvement in depressive symptoms compared only 22% of patients given the antidepressant drug imipramine. Unlike conventional antidepressant drugs that produce adverse side effects, SAMe produces multiple health benefits and may slow the aging process.
The March 1997 issue of Life Extension Magazine provides strong scientific evidence that SAMe is effective in the treatment of depression, schizophrenia, demyelination diseases, liver disease, dementia, arthritis, and other conditions. Recently, the Journal of Neurochemistry reported the brain levels of SAMe in Alzheimer's patients are severely decreased.
SAMe Costs Too Much!
SAMe is a natural metabolite of the amino acid methionine. It is sold in Europe as a drug for the treatment of depression and liver disease. The European version of SAMe is cost prohibitive for most people. The cost of an effective dose (1200-1600 mg) for treating most forms of depression and acute liver disease is $9 to $12 a day.
Dmg O Tmg Autismo
Unlike many drugs that have inflated prices, SAMe is genuinely very expensive to synthesize. It takes many kilos of methionine to produce 1 kilo of SAMe. Stability in manufacturing and packaging are further problems that add to the cost of SAMe.The Foundation is working with American laboratories to produce SAMe at a more affordable price. One of these laboratories has already developed a more cost effective synthesizing technique, but it will take time to bring SAMe into full production and, even then, SAMe may still cost more than most people can afford.
A Cost Effective Way of Boosting SAMe Levels
Here's how SAMe can be boosted naturally within the body: When homocysteine is converted into methionine within the body, a by-product of this conversion is S-adenosylmethionine (SAMe). Homocysteine is amino acid, which has been linked to the development of atherosclerosis, coronary artery disease and stroke. A study in The Journal of the American Medical Association (JAMA) showed that those with high homocysteine levels had a 3.4 times greater risk of a heart attack than those with low homocysteine levels.
Conventional medical journals such as JAMA have recommended vitamin supplements such as folic acid as safe methods of lowering homocysteine. A more effective nutrient to lower homocysteine is trimethylglycine (TMG). TMG converts homocysteine into methionine and, in the process, produces S-adenosylmethionine (SAMe). Unlike the synthetic SAMe drug available from Europe, TMG is inexpensive and is readily available as a dietary supplement. In order to further describe how TMG works, we will introduce a new concept called 'methylation enhancement' and describe how this may relate to aging.
A Cell Rejuvenating Event
Methylation can be defined as the process of putting a methyl group onto a DNA molecule. Published research shows three specific benefits of enhancing methylation:
- Methylation lowers dangerous homocysteine levels, thus lowering the risk of heart disease and stroke. Methylation is the primary process by which homocysteine is transformed into nontoxic compounds such as SAMe.
- Methylation produces SAMe, which may have potent anti-aging effects, and has been shown to alleviate depression, remylenate nerve cells, improve Alzheimer's and Parkinson's disease patients, and protect against alcohol-induced liver injury.
- Methylation protects DNA. Methyl groups appear to prevent genes that cause diseases from being expressed. Protecting DNA may reduce the risk of genetically induced cancers in addition to slowing cellular aging.
Factors that decrease methylation include smoking, alcohol consumption, high fat diets, birth control pills and aging. As animals age, their methylation activity declines progressively. This decline in methylation is directly related to the physical decline associated with aging. Published research shows that 'methylation' is related to a variety of disease states including cardiovascular disease, cancer, liver disease, and neurological disorders.
TMG and SAMe both facilitate youthful methylation metabolism. Enhancing methylation not only protects against many diseases, but may make people feel younger. Optimal methylation occurs in young women of child bearing age, but even some of these women suffer from a methylation deficiency that can produce a wide range of disease states. These women can be helped by following a methylation enhancing program.
Methylation - Enhancing Protocol
Trimethylglycine (TMG) is the most effective methylation enhancing agent known. After TMG converts toxic homocysteine into methionine and SAMe, it becomes DMG (dimethylglycine), the first nutrient performance enhancer sold in the United States in health food stores.
TMG is extracted from sugar beets. It has a distinctive taste that is mildly sweet with a mild aftertaste. TMG is also known as glycine betaine. Some vitamin companies confuse 'betaine hydrochloride' with glycine betaine (TMG). Betaine HCL does not provide the methylation enhancement of TMG and could elevate stomach acidity in some people. There are no reports of side effects with TMG other than brief muscle tension headaches if it is taken in large quantities without food.
Dmg Benefits And Side Effects
Fortunately, the cost of 99% pure trimethylglycine is low, thus enabling Foundation members to take high enough doses of TMG to significantly enhance methylation and SAMe levels.
Foundation members have been obtaining potent doses of methylation enhancing nutrients in LIFE EXTENSION MIX,LIFE EXTENSION BOOSTER and CHLOROPHYLLIN. These formulas include the maximum amount of folic acid permitted by the FDA (for pregnant women). Other methylation enhancing nutrients are vitamin B12 and choline. (Vitamin B6 lowers homocysteine levels via a different mechanism than methylation enhancement.)
Studies show that while folic acid can lower homocysteine levels in most people, TMG can cause homocysteine to disappear from plasma after one to three months of administration. TMG stimulates methylation more effectively than folic acid and other vitamins.
A minimum effective dose of TMG for homocysteine reduction is 500- 1,000 mg a day. Optimal doses for methylation enhancement and SAMe elevation are about 3,000 mg a day. In some studies, 6,000 mg a day of TMG were used.
Important note: In a minority of people who suffer from elevated homocysteine, it is necessary B6. These people lack an enzyme required to convert homocysteine into methionine and SAMe. The doses of vitamin B6 required are 500 to 1,500 mg a day. This much vitamin B6 may cause peripheral nerve damage if taken over a multi-year period of time. Other B-complex vitamins, magnesium, carnitine, omega 3 fatty acids, and alpha lipoic acid may reduce the risk of nerve damage in those have to take high doses of vitamin B6 to keep homocysteine levels within a safe range.
Description
Dimethylglycine (DMG) is a versatile, health-building, anti-aging and healing nutrient derived from the amino acid Glycine. It is very important for optimal health and is produced by all animals and humans in small amounts. Our bodies use DMG every moment of every day to affect nearly every metabolic pathway in the body. It’s a building block for the synthesis of methionine, choline, important hormones, neurotransmitters and DNA. Dimethylglycine is found in certain foods such as beans, pumpkin seeds and liver; however, nearly everyone can benefit from supplementing their diet with higher levels of DMG.
Feel Young Again, Age Gracefully
Dimethylglycine is known as one of the most effective anti-aging nutrient in the world. DMG helps you to feel young, vital, healthy and strong well into old age. It boosts strength, endurance and stamina by dramatically improving the nutritional environment of the cells. This in turn causes the tissues and organs of the body to function more efficiently and with more youthful vitality, no matter how old you are.
Aging decreases immunity, but dimethylglycine helps enhance immunity to slow the aging process. DMG helps us to age more gracefully. As we get older, free radicals and stress damage one’s ability to maintain immune system function, memory and physical ability. DMG helps us cope with stress, increases tolerance to physical activity and helps us fight fatigue as well as improving stamina, sexual function, athletic ability and mental acuity.
In her best selling book, Breakthrough: Eight Steps to Wellness, actress and best-selling author Suzanne Somers calls DMG a critical nutritional supplement. She is well into her 60s and is still radiant and stunningly beautiful. Dr. Ray Sahelian, M.D., bestselling author of Mind Boosters: Improve Your Mind, Memory, and Mood wrote, “If you find the field of mind-boosting pills, sex nutrients, and anti-aging interesting, you will certainly want to learn more about DMG (dimethylglycine).” He’s among many medical professionals that acknowledge the very pronounced benefits of dimethylglycine, such as increased energy, an overall feeling of well-being, faster thinking, enhanced memory and particularly greater stamina throughout the day. In other words, you don’t burn out as easily in the course of a normal day.
Numerous Health Benefits from Taking DMG
The health benefits from supplementing with DMG are significant. Dimethylglycine greatly improves the nutritional environment of the cell, increases immune system function (between up to 300% and 1000%) and improves oxygen utilization which enhances energy levels in the body. It helps to optimize mental activity and brain function and supports the body in counteracting the negative effects of mental and physical stress. DMG is one of the best anti-aging nutrients on the market.
Dimethylglycine is a major anti-stress nutrient, energy builder and adaptogen that benefits your metabolism, health and well-being. The average person has fatigue issues, injuries, gets sick and is generally stressed out. When the body is under conditions of stress, DMG improves oxygen utilization in the body and enhances cellular metabolism. Studies show that DMG supplementation helps both humans and animals adapt to increased physical activity by reducing blood lactic acid levels, increasing oxygen uptake by tissues, enhancing ATP production, normalizing glucose metabolism and decreasing fatigue. DMG reduces lactic acid build up in the muscle thereby shortening recovery time after strenuous exercise and improving endurance. Dimethylglycine:
- Helps stimulate and maintain a strong immune system
- Improves metabolism
- Optimizes energy levels
- Makes energy production more efficient
- Reduces lactic acid formation
- Minimizes cravings for alcohol and drugs
- Enhances detoxification of the blood and the liver
- Increases oxygen utilization
- Enhances methyl donation
- Acts as an adaptogen
- Enhances neurotransmitter production
- Improves circulation
- Helps the body adapt to stress
- Decreases homocysteine levels
- Increases glutathione and SAMe levels
- Decreases elevated blood pressure, triglyceride and cholesterol levels
- Acts as an antioxidant
- Promotes the neutralization of free radicals
- Has anti-inflammatory properties
- Provides building blocks needed for synthesis of important body constituents
- Supports lymphocyte production
In the nation’s #1 bestselling guide to natural remedies, Prescription for Nutritional Healing, authors James Balch, M.D., and Phyllis Balch, C.N.C. recommend using DMG for 48 condition-specific uses. DMG is useful in so many conditions in part because it is a metabolic enhancer. As Dr. Balch writes, “Taking supplemental DMG can have a wide range of beneficial effects, including helping the body maintain high energy levels and boosting mental acuity. DMG has been found to enhance the immune system, and to reduce elevated blood cholesterol and triglyceride levels. It improves oxygen utilization by the body, helps to normalize blood pressure and blood glucose levels, and improves the functioning of many important organs.”
How Does Dimethylglycine Work in the Body?
Dimethylglycine is an important methyl donor that participates in numerous biochemical pathways and is important for glutathione synthesis. It’s able to donate a methyl towards necessary enzymatic reactions. This ability to donate one of its methyls is very crucial in the synthesis and production of important brain chemicals. Sufficient levels of glycine in the body are responsible for a general overall feeling of health or well being.
A methyl donor is simply any substance that can transfer a methyl group [a carbon atom attached to three hydrogen atoms (CH3)] to another substance. Methylation is a biochemical process that is essential to life, health and regeneration of body cells. Vitamins, hormones, neurotransmitters, enzymes, nucleic acids (DNA and RNA), and antibodies depend on the transfer of methyl groups to complete their synthesis. Scientists suspect that proper methylation of DNA may prevent the expression of harmful genes, such as cancer genes. Our body’s ability to methylate declines with age, contributing to the aging process, and therefore supplementation can be beneficial.
The versatility of Dimethylglycine to donate methyl groups and generate molecules like glycine, serine, sarcosine, ethanolamines, methionine and cysteine, as well as contributing to the formation of SAMe, may explain why DMG has such broad and wide-reaching therapeutic effects on the body. Some of those therapeutic effects include enhancing energy production, increasing circulation, decreasing seizure activity, reducing lactic acid levels, promoting better oxygen utilization, lowering homocysteine and many other beneficial effects.
Is DMG New?
Dimethylglycine in supplement form has been around for over 40 years with numerous clinical studies to prove its benefits and safety. DMG was first discovered by Russian scientists who were looking for a solution to the problem of accelerated aging in cosmonauts in space. Through performing hundreds of research studies, they found that returning cosmonauts who used DMG showed no symptoms of cellular damage or premature aging that the other cosmonauts all displayed.
Originally called “vitamin B-15” or “calcium pangamate” in the 1960’s and 1970’s, dimethylglycine has been cherished by top athletes and sports professionals for its ability to enhance performance and increase endurance. Olympic greats, world-champion body-builders, Super Bowl champions and the heavyweight champion of the world have all attributed their success in part to supplementing with DMG.
Aging and over-the-hill athletes notice especially good results from taking DMG. During an internationally televised interview with Muhammad Ali in 1976, the boxing champ held up a bottle of “B-15” (DMG) to show the world his “secret weapon.” As reported in the National Medical Bulletin in 1978, Ali took DMG during his many consecutive victories, and then when he stopped taking it, he was defeated by a newcomer. Once he began taking DMG again, he beat that same newcomer in a rematch in 1978.
Is DMG Safe?
Dimethylglycine has a long history of safe use by humans and is an intricate part of human metabolism. DMG is absolutely required by the human body to function optimally. DMG is hypoallergenic and is an extremely safe food substance that can enhance normal metabolic pathways in the body. It is safe for use in children of all ages. Doctors have been recommending DMG for autistic children since 1980.
Extensive animal studies on the safety of dimethylglycine showed that it is actually as safe as vitamin C. It is literally impossible to overdose. DMG actually has protective abilities against mutagens and carcinogens that may be in our food, water and the air we breathe.
Paul Buck, Ph. D., nutritional biochemist at an FDA approved laboratory in Waverly, NY, is quoted to have said that “the average person would have to ingest 21 pounds or more of DMG in a short amount of time for it to be toxic, and at that point it would be a problem more with the volume than with the actual toxicity of the DMG.”
Dr. Gary Todd, M.D., describes DMG safety in his book entitled Nutrition, Health and Disease on page 206. Dr. Todd summarizes the extreme safety of DMG with this illustration: “the average DMG tablet is 125 mg, so you would have to take 4,144 tablets in a single dose to achieve the LD50 for the average 70 kg (154 lb.) male, which would cost you $1,167.23. The intake of this much DMG would take an impossibly long time to swallow all the tablets, so a toxic dose would be impossible in humans, considering it would take almost 50 liters of water to swallow the pills, which in itself is a lethal dose.”
Why Take DMG?
Dimethylglycine is absolutely essential to virtually all human biological functions. DMG plays a key role in at least 41 different biochemical processes that are directly linked to how the body ages. DMG is required by all 70 trillion cells of the body for everything from proper nutrient absorption to cellular metabolism and energy production to oxygenation of the bloodstream. Dimethylglycine increases neuron activity and brain function, promotes healthy heart function, supports proper liver function and detoxification, enhances immune system function, and is generally essential to virtually all human biological function, including the production of DNA.
The body makes DMG, but not in sufficient levels to counter the many stress factors that assault the body today. Unfortunately, the body makes less and less dimethylglycine as we age. DMG is an anti-stress nutrient and metabolic enhancer, which provides a wide spectrum of benefits to health, vitality and wellness. It also has many healing and therapeutic benefits. Therefore, for optimal health, most people will notice significant improvement when taking DMG. The specific benefits that a person will receive from taking DMG are very unique to that person’s overall health, lifestyle, age and stress level.
How to Take DMG
Dimethylglycine is quickly broken down in the body, so smaller doses multiple times a day is best rather than taking it all at once. It is best to take DMG several times throughout the day in order to maintain consistent availability to the body. May be taken with out without food.
Dimethylglycine is best taken between meals to avoid competitive uptake from other amino acids although it can be taken with food as well. Individuals with heavy work schedules, high stress, athletes or people dealing with a major health problem can benefit from higher intakes of DMG. Depending on the specific area of use, the recommended dosage of DMG can range anywhere from 125mg to over 1000mg a day. An additional 150mg to 300mg can be taken for every 2 to 4 hours of exercise or heavy stress. Due to biochemical individuality, results can show up anywhere from a few days to a few weeks.
In Conclusion
DMG can help you live a longer, better and healthier life. It can add years to your life and life to your years. Dimethylglycine is a safe, effective and natural way to build wellness and optimize health. Taking DMG is a practical way to support well-being, cope with stress, slow the aging process and allow us to stay healthier by fortifying our body against dis-ease. Mountain Well-Being is the source for pure, high quality DMG packaged in convenient chewable tablets. Instead of the usual 60 count bottles, Mountain Well-Being DMG comes in packages containing a full 90 chewable tablets of dimethylglycine. At 250 mg per capsule, ours is double the strength as most other brands.
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